Sstr4^tm1Szo
Targeted Allele Detail

Summary

• Symbol: Sstr4^tm1Szo
• Name: somatostatin receptor 4; targeted mutation 1, Janos Szolcsanyi
• MGI ID: MGI:4355975
• Gene: Sstr4 Location: Chr2:148237297-148238684 bp, + strand Genetic Position: Chr2, 73.44 cM
• Alliance: Sstr4^tm1Szo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152015
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The lone coding exon was replaced with a LacZ cassette and a floxed neomycin resistance gene. Founder mice were crossed with cre transgenic mice to remove the neomycin selection cassette from the germline. Endogenous gene inactivation and reporter gene expression were confirmed by RT-PCR analysis of brain extracts. (J:152015)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sstr4 Mutation: 19 strains or lines available

References

• Original: J:152015 Helyes Z, et al., Impaired defense mechanism against inflammation, hyperalgesia, and airway hyperreactivity in somatostatin 4 receptor gene-deleted mice. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13088-93
• All: 7 reference(s)