Epn1^tm1Ocr
Targeted Allele Detail

Summary

• Symbol: Epn1^tm1Ocr
• Name: epsin 1; targeted mutation 1, Ottavio Cremona
• MGI ID: MGI:4356015
• Gene: Epn1 Location: Chr7:5083234-5101177 bp, + strand Genetic Position: Chr7, 2.94 cM
• Alliance: Epn1^tm1Ocr page

Major developmental defects in Epn1^tm1Ocr/Epn1^tm1Ocr Epn2^tm1Ocr/Epn2^tm1Ocr embryos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151951
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' end of the first coding exon and the 5'end of the following intron were replaced with a neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in multiple tissues from homozygous mice. (J:151951)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epn1 Mutation: 33 strains or lines available

References

• Original: J:151951 Chen H, et al., Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13838-43
• All: 2 reference(s)