Pcdha^tm5.1Tyag
Targeted Allele Detail

Summary

• Symbol: Pcdha^tm5.1Tyag
• Name: protocadherin alpha cluster; targeted mutation 5.1, Takeshi Yagi
• MGI ID: MGI:4356090
• Synonyms: Pcdha^deltaA
• Gene: Pcdha Location: unknown Genetic Position: Chr18, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151979
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: An in-frame termination codon was inserted just after the A and B common region in the constant region third exon along with a floxed neomycin resistance gene cassette. The neo cassette was removed by germ line cre-mediated recombination. Mice do not produce the B-type transcript but instead only a truncated transcript that lacks A-type cytoplasmic tail. (J:151979)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pcdha Mutation: 52 strains or lines available

References

• Original: J:151979 Katori S, et al., Protocadherin-alpha family is required for serotonergic projections to appropriately innervate target brain areas. J Neurosci. 2009 Jul 22;29(29):9137-47
• All: 3 reference(s)