Prickle1^tm1Nue
Targeted Allele Detail

Summary

• Symbol: Prickle1^tm1Nue
• Name: prickle planar cell polarity protein 1; targeted mutation 1, Naoto Ueno
• MGI ID: MGI:4356107
• Synonyms: Prickle1^LacZ
• Gene: Prickle1 Location: Chr15:93396995-93493772 bp, - strand Genetic Position: Chr15, 47.69 cM
• Alliance: Prickle1^tm1Nue page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151993
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 was replaced with a lacZ-neo cassette via homologous recombination. Immunofluorescent analysis of homozygous embryos confirmed the absence of protein expression. (J:151993)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prickle1 Mutation: 34 strains or lines available

References

• Original: J:151993 Tao H, et al., Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14426-31
• All: 5 reference(s)