Tcra^Ln1Ogu
Allele Detail

Summary

• Symbol: Tcra^Ln1Ogu
• Name: T cell receptor alpha chain; recombination line 1, Atsuo Ogura
• MGI ID: MGI:4356137
• Synonyms: Clone 1, NKT, Valpha14-Jalpha18, Valpha14-Jalpha281
• Gene: Tcra Location: Chr14:52665424-54461655 bp, + strand Genetic Position: Chr14, cytoband D1-D2

Mutation origin

• Strain of Origin: (C57BL/6 x 129/Sv)F1

Mutation description

• Allele Type: Not Applicable
• Mutation: Other
• Mutation details: This allele was created by transfer of a male natural killer T cells nucleus (C57BL/6 x 129/Sv)F1 background) into an enucleated oocyte. A blastocyte was grown and transferred into pseudopregnant mouse. One of the Tcra alleles in the transferred nuclei had a productive, in-frame recombination of the Valpha14-Jalpha281 gene segments and it was this allele that was propagated. Sequence analysis determined this productive recombination occurred on the genetic locus contributed by the C57BL/6 parent. (J:152069)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcra Mutation: 101 strains or lines available

References

• Original: J:152069 Inoue K, et al., Generation of cloned mice by direct nuclear transfer from natural killer T cells. Curr Biol. 2005 Jun 21;15(12):1114-8
• All: 2 reference(s)