Tcrb^Ln2Ogu
Allele Detail

Summary

• Symbol: Tcrb^Ln2Ogu
• Name: T cell receptor beta chain; recombination line 2, Atsuo Ogura
• MGI ID: MGI:4356142
• Synonyms: clone 2, NKT, Vbeta8
• Gene: Tcrb Location: Chr6:40868230-41535305 bp, + strand Genetic Position: Chr6, cytoband A-C

Mutation origin

• Strain of Origin: (C57BL/6 x 129/Sv)F1

Mutation description

• Allele Type: Not Applicable
• Mutation: Other
• Mutation details: This allele was created by transfer of a male natural killer T cells nucleus (C57BL/6 x 129/Sv)F1 background) into an enucleated oocyte. A blastocyte was grown and transferred into pseudopregnant mouse. One of the Tcrb alleles in the transferred nuclei had a productive, in-frame recombination of the Vbeta8S3-Dbeta1-Jbeta1S4 segments and it was this allele that was propagated. Sequence analysis determined this productive recombination occurred on the genetic locus contributed by the 129/Sv parent. (J:152069)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Tcra^Ln2Ogu/Tcra^+ Tcrb^Ln2Ogu/Tcrb^+	involves: 129/Sv * C57BL/6

Phenotypes:

Affected Systems	cx1
show or hide all annotated terms
growth/size/body	√
increased body weight	√
hematopoietic system	√
abnormal T cell morphology	√
immune system	√
abnormal T cell morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcrb Mutation: 97 strains or lines available

References

• Original: J:152069 Inoue K, et al., Generation of cloned mice by direct nuclear transfer from natural killer T cells. Curr Biol. 2005 Jun 21;15(12):1114-8
• All: 1 reference(s)