Hip1^tm4Tsr
Targeted Allele Detail

Summary

• Symbol: Hip1^tm4Tsr
• Name: huntingtin interacting protein 1; targeted mutation 4, Theodora S Ross
• MGI ID: MGI:4356264
• Synonyms: Hip1^LSL-H/P
• Gene: Hip1 Location: Chr5:135435385-135573974 bp, - strand Genetic Position: Chr5, 75.18 cM, cytoband F-G2
• Alliance: Hip1^tm4Tsr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151974
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed STOP cassette was inserted upstream of exon 2. Exons 3 through 7 were replaced with a fusion of human HIP1 and PDGFRB, to model human t(5;7) translocation, and a neo cassette. Removal of the STOP cassette is required for expression of the fusion gene. (J:151974)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hip1 Mutation: 67 strains or lines available

References

• Original: J:151974 Oravecz-Wilson KI, et al., Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder. Cancer Cell. 2009 Aug 4;16(2):137-48
• All: 2 reference(s)