Ccdc86^tm1Hfuj
Targeted Allele Detail

Summary

• Symbol: Ccdc86^tm1Hfuj
• Name: coiled-coil domain containing 86; targeted mutation 1, Hodaka Fujii
• MGI ID: MGI:4356276
• Synonyms: Cyclon^EN
• Gene: Ccdc86 Location: Chr19:10918845-10926630 bp, - strand Genetic Position: Chr19, 7.41 cM, cytoband B
• Alliance: Ccdc86^tm1Hfuj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151722
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An EGFP cassette and a neomycin resistance gene were placed immediately downstream of ATG start site located in exon 1 of the gene. Correct targeting was confirmed by Southern blotting. Activated lymphocytes from heterozygote mice had 3-fold reduced levels of endogenous gene product compared to controls as determined by quantitative PCR. (J:151722)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccdc86 Mutation: 16 strains or lines available

References

• Original: J:151722 Saint Fleur S, et al., Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon. Blood. 2009 Aug 13;114(7):1355-65
• All: 1 reference(s)