Lrrk2^tm1.1Shn
Targeted Allele Detail

Summary

• Symbol: Lrrk2^tm1.1Shn
• Name: leucine-rich repeat kinase 2; targeted mutation 1.1, Jie Shen
• MGI ID: MGI:4356349
• Synonyms: Lrrk2^R1441C
• Gene: Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
• Alliance: Lrrk2^tm1.1Shn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151944
• Parent Cell Line: MKV6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129)F1

Mutation description

Allele Type: Targeted (Humanized sequence) Mutations: Insertion, Nucleotide substitutions Mutation details: Exon 31 was replaced with one in which nucleotide substitutions led to the amino acid substitution of cysteine for arginine at position 1441 (R1441C), mimicking a mutation found in xome Parkinson's disease patients. A floxed neo cassette was inserted downstream of the modified exon and removed by transient cre expression in ES cells. (J:151944)

Generation of the Lrrk2^tm1.1Shn allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lrrk2 Mutation: 159 strains or lines available

References

• Original: J:151944 Tong Y, et al., R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14622-7
• All: 15 reference(s)