Snord116^tm1Jbro
Targeted Allele Detail

Summary

• Symbol: Snord116^tm1Jbro
• Name: small nucleolar RNA, C/D box 116 cluster; targeted mutation 1, Jurgen Brosius
• MGI ID: MGI:4356428
• Synonyms: PWScr^5'LoxP
• Gene: Snord116 Location: unknown Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152022
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (No functional change, Not Applicable)
• Mutation: Insertion
• Mutation details: A cassette containing the 5' half of the HPRT mini-gene (driven by the Pgk promoter), a loxP site and a neomycin resistance gene (driven by the Polr2a promoter), was inserted 5' of Snord116. Mice with this allele don't display a discernible phenotype. When expressed from the maternal allele, this construct forces the expression of the snoRNA genes in the, normally maternally imprinted, Snord116 and Snord115 clusters. (J:152022)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snord116 Mutation: 3 strains or lines available

Notes

Cre mediated recombination of this allele in combination with Ipw^tm1Jbro yields Del(7Ipw-Snord116)1Jbro.

References

• Original: J:152022 Skryabin BV, et al., Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation. PLoS Genet. 2007 Dec 28;3(12):e235
• All: 3 reference(s)