Del(7Ipw-Snord116)1Jbro
Targeted Allele Detail

Summary

• Symbol: Del(7Ipw-Snord116)1Jbro
• Name: deletion, chr 7, Jurgen Brosius 1
• MGI ID: MGI:4356431
• Synonyms: Del1Jbro, PWScr^-
• Gene: Del(7Ipw-Snord116)1Jbro Location: unknown Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152022
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(7Ipw-Snord116)1Jbro involves 68 genes/genome features (Snhg14, Ipw, Gm23862 ...) View all
• Mutation details: A cassette containing the 5' half of the HPRT mini-gene, a loxP site and a neomycin resistance gene was inserted 5' of Snord116 (Snord116^tm1Jbro) and a cassette containing a puromycin resistance gene gene, a loxP site, and the 3' half of the HPRT mini-gene was inserted 3' of Ipw (Ipw^tm1Jbro). Transient cre expression in ES cells deleted both genes/gene clusters. This region is termed the Prader-Willi Syndrome critical region (PWScr). (J:152022)

Disease models

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(7Ipw-Snord116)1Jbro Mutation: 0 strains or lines available

References

• Original: J:152022 Skryabin BV, et al., Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation. PLoS Genet. 2007 Dec 28;3(12):e235
• All: 8 reference(s)