FtoI367F
Chemically induced Allele Detail
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Symbol: |
FtoI367F |
Name: |
FTO alpha-ketoglutarate dependent dioxygenase; Ile 367 Phe |
MGI ID: |
MGI:4356560 |
Gene: |
Fto Location: Chr8:92040153-92395067 bp, + strand Genetic Position: Chr8, 44.34 cM
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Alliance: |
FtoI367F page
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Strain of Origin: |
Not Specified
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Allele Type: |
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Chemically induced (ENU) |
Mutation: |
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Single point mutation
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Mutation details: ENU mutagenesis induced a missense mutation (A->T) in exon 6 and results in the amino acid substitution of phenylalanine with isoleucine at residue 367 (I367F). This mutation is predicted to affect protein dimerization.
(J:152163)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: C3H/HeH * C57BL/6J | | | | involves: C3H/HeH * C57BL/6J | |
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Phenotypes: |
Affected Systems |
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adipose tissue
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decreased total body fat amount
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decreased percent body fat/body weight
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growth/size/body
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√
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√
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increased lean body mass
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√
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decreased body weight
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√
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homeostasis/metabolism
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√
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increased circulating glucose level
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increased circulating glucagon level
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decreased circulating insulin level
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increased circulating leptin level
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increased circulating cholesterol level
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increased circulating HDL cholesterol level
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increased circulating triglyceride level
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abnormal urine catecholamine level
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decreased carbon dioxide production
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increased carbon dioxide production
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increased oxygen consumption
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√
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increased respiratory quotient
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√
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abnormal metabolism
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√
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renal/urinary system
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√
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abnormal urine catecholamine level
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:152163 Church C, et al., A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet. 2009 Aug;5(8):e1000599 |
All: |
2 reference(s) |
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