Fto^I367F
Chemically induced Allele Detail

Summary

• Symbol: Fto^I367F
• Name: FTO alpha-ketoglutarate dependent dioxygenase; Ile 367 Phe
• MGI ID: MGI:4356560
• Gene: Fto Location: Chr8:92040153-92395067 bp, + strand Genetic Position: Chr8, 44.34 cM
• Alliance: Fto^I367F page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a missense mutation (A->T) in exon 6 and results in the amino acid substitution of phenylalanine with isoleucine at residue 367 (I367F). This mutation is predicted to affect protein dimerization. (J:152163)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fto Mutation: 75 strains or lines available

References

• Original: J:152163 Church C, et al., A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet. 2009 Aug;5(8):e1000599
• All: 2 reference(s)