Map3k14^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Map3k14^m1Btlr
• Name: mitogen-activated protein kinase kinase kinase 14; mutation 1, Bruce Beutler
• MGI ID: MGI:4357692
• Synonyms: lucky
• Gene: Map3k14 Location: Chr11:103110590-103158227 bp, - strand Genetic Position: Chr11, 66.8 cM
• Alliance: Map3k14^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, identified in a screen of G3 progeny of an ENU mutagenized mouse for failure to mount a humoral immune response to a model antigen, comprises a C to T transition at nucleotide position 1269 of the genomic sequence, in the sixth of the gene's 16 exons. It replaces the codon specifying arginine at position 396 with a termination codon (R396Ter). (J:152065)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Map3k14 Mutation: 41 strains or lines available

References

• Original: J:152065 Arnold CN, et al., Record for "lucky", updated 25 Aug 2009 (Accessed 3 September 2009). MGI Direct Data Submission. 2009
• All: 2 reference(s)