Asz1^tm1Zuk
Targeted Allele Detail

Summary

• Symbol: Asz1^tm1Zuk
• Name: ankyrin repeat, SAM and basic leucine zipper domain containing 1; targeted mutation 1, Martin M Matzuk
• MGI ID: MGI:4357768
• Synonyms: Gasz^-
• Gene: Asz1 Location: Chr6:18050963-18109060 bp, - strand Genetic Position: Chr6, 8.09 cM
• Alliance: Asz1^tm1Zuk page

Small testes and defective meiosis in Asz1^tm1Zuk/Asz1^tm1Zuk mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152071
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2, which encode the transcriptional start site and the initiation ATG codon, were replaced by a PgkHPRT expression cassette. Correct targeting in HPRT-null ES cells was confirmed by Southern blotting. Gene inactivation was confirmed by immunoblot analysis on homozygous testes extracts. (J:152071)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asz1 Mutation: 27 strains or lines available

References

• Original: J:152071 Ma L, et al., GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet. 2009 Sep;5(9):e1000635
• All: 3 reference(s)