Terf1^tm1.1Blas
Targeted Allele Detail

Summary

• Symbol: Terf1^tm1.1Blas
• Name: telomeric repeat binding factor 1; targeted mutation 1.1, Maria A Blasco
• MGI ID: MGI:4357772
• Synonyms: TRF1^flox
• Gene: Terf1 Location: Chr1:15875870-15914276 bp, + strand Genetic Position: Chr1, 4.88 cM, cytoband E3
• Alliance: Terf1^tm1.1Blas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152077
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in the 5'UTR and an frt flanked neo cassette with a 5' loxP site was inserted into intron 1. Germ line, flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:152077)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Terf1^tm1.1Blas

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Terf1 Mutation: 37 strains or lines available

References

• Original: J:152077 Martinez P, et al., Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev. 2009 Sep 1;23(17):2060-75
• All: 13 reference(s)