Klra17^tm1.1Apma
Targeted Allele Detail

Summary

• Symbol: Klra17^tm1.1Apma
• Name: killer cell lectin-like receptor, subfamily A, member 17; targeted mutation 1.1, Andrew P Makrigiannis
• MGI ID: MGI:4357862
• Synonyms: Ly49q1^lox
• Gene: Klra17 Location: Chr6:129808117-129853635 bp, - strand Genetic Position: Chr6, 63.44 cM
• Alliance: Klra17^tm1.1Apma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152288
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Transient cre expression in ES cells removed the neo cassette leaving a loxP site inserted into exon 2. The insertion interrupts the open reading frame and causes premature termination. The absence of protein expression was confirmed by flow cytometry on plasmacytoid and myeloid dendritic cells. (J:152288)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Klra17 Mutation: 34 strains or lines available

References

• Original: J:152288 Tai LH, et al., Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC. J Exp Med. 2008 Dec 22;205(13):3187-99
• All: 7 reference(s)