Tg(KRT14-cre/Esr1*)3Brst
Transgene Detail

Summary

• Symbol: Tg(KRT14-cre/Esr1*)3Brst
• Name: transgene insertion 3, Barry R Stripp
• MGI ID: MGI:4357971
• Synonyms: K14-CreER^t
• Transgene: Tg(KRT14-cre/Esr1*)3Brst Location: unknown
• Alliance: Tg(KRT14-cre/Esr1*)3Brst page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(KRT14-cre/Esr1*)3Brst expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	KRT14

• Mutation details: The transgenic construct contains the KRT14 promoter/enhancer followed by the cre recombinase cDNA fused to the sequence of an altered hormone-binding domain of the mouse estrogen receptor (cre/Ert). The transgene also contains a rabbit beta-globin 5' UTR region and intronic sequence 5' to the cre cDNA, as well as the KRT14 3' UTR and polyadenylation site 3' to the cre sequence. The construct was injected into FVB/N zygotes. Three founders were identified. (J:150033)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	KRT14 (species not specified) Summary of all recombinase alleles driven by KRT14. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:150033 Hong KU, et al., Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. Am J Pathol. 2004 Feb;164(2):577-88
• All: 8 reference(s)