Tg(CAG-EGFP,-Pax6,-lacZ)1Stoy
Transgene Detail

Summary

• Symbol: Tg(CAG-EGFP,-Pax6,-lacZ)1Stoy
• Name: transgene insertion 1, Anastassia Stoykova
• MGI ID: MGI:4358072
• Synonyms: JoP6
• Transgene: Tg(CAG-EGFP,-Pax6,-lacZ)1Stoy Location: unknown
• Alliance: Tg(CAG-EGFP,-Pax6,-lacZ)1Stoy page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-EGFP,-Pax6,-lacZ)1Stoy expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pax6 (MGI:97490)

• Mutation details: A construct containing the CAGGS promoter driving expression of a loxP-flanked EGFP with a polyA STOP sequence, followed by the (canonical) coding sequence of Pax6 and an IRES-lacZ-polyA cassette was used to generate the mouse line. The allele ubiquitously expresses EGFP. When these mice are crossed to a cre recombinase-expressing line, the STOP-EGFP sequence is excised, allowing coexpression of Pax6 and lacZ. (J:135032)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:135032 Berger J, et al., Conditional activation of Pax6 in the developing cortex of transgenic mice causes progenitor apoptosis. Development. 2007 Apr;134(7):1311-22
• All: 3 reference(s)