Kalrn^tm1Ppen
Targeted Allele Detail

Summary

• Symbol: Kalrn^tm1Ppen
• Name: kalirin, RhoGEF kinase; targeted mutation 1, Peter Penzes
• MGI ID: MGI:4358076
• Gene: Kalrn Location: Chr16:33789443-34393647 bp, - strand Genetic Position: Chr16, 24.27 cM
• Alliance: Kalrn^tm1Ppen page

Brain region specific and age-dependent alterations in spine density in Kalrn^tm1Ppen/Kalrn^tm1Ppen mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152011
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion Mutation details: The genomic sequence from exon 27 through exon 28 was replaced with a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on frontal cortex and hippocampus extracts. (J:152011)

Generation of the Kalrn^tm1Ppen allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kalrn Mutation: 171 strains or lines available

References

• Original: J:152011 Cahill ME, et al., Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13058-63
• All: 7 reference(s)