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Bcl11atm1Pwt
Targeted Allele Detail
Summary
Symbol: Bcl11atm1Pwt
Name: BCL11 transcription factor A; targeted mutation 1, Philip W Tucker
MGI ID: MGI:4358087
Synonyms: Bcl11afl
Gene: Bcl11a  Location: Chr11:24028056-24124123 bp, + strand  Genetic Position: Chr11, 14.41 cM
Alliance: Bcl11atm1Pwt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:151995
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn Frt-flanked neo cassette and lox-P flanked exon 1 were inserted upstream of exon 2. Flp mediated recombination removed the neo-cassette. Cre-mediated recombination will remove exon 1, along with 1.5kb of its upstream sequence containing an ultraconserved noncoding region. (J:151995, J:207383)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl11a Mutation:  44 strains or lines available
References
Original:  J:151995 Sankaran VG, et al., Developmental and species-divergent globin switching are driven by BCL11A. Nature. 2009 Aug 27;460(7259):1093-7
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory