Bcl11a^tm1Pwt
Targeted Allele Detail

Summary

• Symbol: Bcl11a^tm1Pwt
• Name: BCL11 transcription factor A; targeted mutation 1, Philip W Tucker
• MGI ID: MGI:4358087
• Synonyms: Bcl11a^fl
• Gene: Bcl11a Location: Chr11:24028056-24124123 bp, + strand Genetic Position: Chr11, 14.41 cM
• Alliance: Bcl11a^tm1Pwt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151995
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An Frt-flanked neo cassette and lox-P flanked exon 1 were inserted upstream of exon 2. Flp mediated recombination removed the neo-cassette. Cre-mediated recombination will remove exon 1, along with 1.5kb of its upstream sequence containing an ultraconserved noncoding region. (J:151995, J:207383)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl11a Mutation: 44 strains or lines available

References

• Original: J:151995 Sankaran VG, et al., Developmental and species-divergent globin switching are driven by BCL11A. Nature. 2009 Aug 27;460(7259):1093-7
• All: 8 reference(s)