Bcl11a^tm1.1Pwt
Targeted Allele Detail

Summary

• Symbol: Bcl11a^tm1.1Pwt
• Name: BCL11 transcription factor A; targeted mutation 1.1, Philip W Tucker
• MGI ID: MGI:4358088
• Gene: Bcl11a Location: Chr11:24028056-24124123 bp, + strand Genetic Position: Chr11, 14.41 cM
• Alliance: Bcl11a^tm1.1Pwt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151995
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Mice containing the floxed Bcl11a^tm1Pwt allele were crossed with Gata1-cre mice to create a null allele in the germline. No protein from the locus was detected in immunoblot analysis of liver extracts from homozygote E18.5 embryos. (J:151995)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl11a Mutation: 44 strains or lines available

References

• Original: J:151995 Sankaran VG, et al., Developmental and species-divergent globin switching are driven by BCL11A. Nature. 2009 Aug 27;460(7259):1093-7
• All: 4 reference(s)