Npr2^pwe
Spontaneous Allele Detail

Summary

• Symbol: Npr2^pwe
• Name: natriuretic peptide receptor 2; peewee
• MGI ID: MGI:4358115
• Gene: Npr2 Location: Chr4:43631935-43651244 bp, + strand Genetic Position: Chr4, 23.05 cM
• Alliance: Npr2^pwe page

Mutation origin

• Strain of Origin: NAW

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Npr2^pwe involves 1 genes/genome features (Npr2) View all
• Mutation details: The peewee mutation is a 4 base pair deletion that alters codon 313 from leucine to a premature stop (L313X) in exon 3 within the ligand binding domain. The truncated protein is predicted to be nonfunctional. (J:188839)
• Inheritance: Recessive

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npr2 Mutation: 63 strains or lines available

References

• Original: J:105913 Moran JL, et al., Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse. Genome Res. 2006 Mar;16(3):436-40
• All: 2 reference(s)