Tg(KRT5-cre/ERT2)1Blh
Transgene Detail

Summary

• Symbol: Tg(KRT5-cre/ERT2)1Blh
• Name: transgene insertion 1, Brigid L Hogan
• MGI ID: MGI:4358332
• Synonyms: CK5-CreER^T2, KRT5-CreER^T2
• Transgene: Tg(KRT5-cre/ERT2)1Blh Location: unknown
• Alliance: Tg(KRT5-cre/ERT2)1Blh page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(KRT5-cre/ERT2)1Blh expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  KRT5 (3852)

  Krt5	(MGI:96702)

• Mutation details: The 6-kb human keratin 5 (KRT5) promoter drives a cre/ERT2 cassette. The cre/ERT2 is flanked by an intron and a polyadenylation sequence from the pCI mammalian expression vector. The construct was injected into fertilized zygotes. 11 founder lines were obtained, and 1 line that gave robust recombination in tracheal basal cells was propagated and maintained on a C57BL/6 x C3H background. (J:152012)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	KRT5 (human) Summary of all recombinase alleles driven by KRT5. Comparative matrix view of recombinase activities Alliance human KRT5 gene page

Tumor Data

List all tumor models in MMHCdb carrying Tg(KRT5-cre/ERT2)1Blh

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:152012 Rock JR, et al., Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12771-5
• All: 30 reference(s)