Tln2^tm1.1Crit
Targeted Allele Detail

Summary

• Symbol: Tln2^tm1.1Crit
• Name: talin 2; targeted mutation 1.1, David R Critchley
• MGI ID: MGI:4358355
• Synonyms: T2-, T2KO
• Gene: Tln2 Location: Chr9:67124369-67466985 bp, - strand Genetic Position: Chr9, 36.39 cM
• Alliance: Tln2^tm1.1Crit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152372
• Parent Cell Line: E14.1a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: This allele was generated from Tln2^tm1Crit by crossing mice to a Cre expressing line resulting in deletion of the entire loxP flanked region (Neo cassette and the first coding exon). The absence of protein expression ws confirmed by western blot analysis and immunohistochemistry on muscle tissues. (J:152372)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tln2 Mutation: 149 strains or lines available

References

• Original: J:152372 Monkley SJ, Targeted alleles of Tln2. MGI Direct Data Submission. 2009
• All: 6 reference(s)