Tln2^tm2Crit
Targeted Allele Detail

Summary

• Symbol: Tln2^tm2Crit
• Name: talin 2; targeted mutation 2, David R Critchley
• MGI ID: MGI:4358373
• Synonyms: T2BD, T2CD, Talin2 CDS deleted, Tln2^cd
• Gene: Tln2 Location: Chr9:67124369-67466985 bp, - strand Genetic Position: Chr9, 36.39 cM
• Alliance: Tln2^tm2Crit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152372
• Parent Cell Line: E14.1a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated by flanking the entire coding sequence (exon1-56) with loxP sites and then deleting them in ES cells. These ES cells were then used to generate mice. Western blot analysis confirmed the absence of protein expression. (J:152372, J:190037)

Expression

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tln2 Mutation: 149 strains or lines available

References

• Original: J:152372 Monkley SJ, Targeted alleles of Tln2. MGI Direct Data Submission. 2009
• All: 4 reference(s)