Nanos3^{tm2.1(cre)Ysa}
Targeted Allele Detail

Summary

• Symbol: Nanos3^{tm2.1(cre)Ysa}
• Name: nanos C2HC-type zinc finger 3; targeted mutation 2.1, Yumiko Saga
• MGI ID: MGI:4358405
• Synonyms: Nanos3^Cre
• Gene: Nanos3 Location: Chr8:84900359-84911396 bp, - strand Genetic Position: Chr8, 40.45 cM
• Alliance: Nanos3^{tm2.1(cre)Ysa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136687
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Nanos3^{tm2.1(cre)Ysa} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nanos3 (MGI:2675387)

• Mutation details: The coding sequence for Cre recombinase, followed by the SV40 polyadenylation signal and a single frt site, resides in the first coding intron of the endogenous gene immediately following the ATG translation initiation codon. (J:136687)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nanos3 (mouse) Summary of all recombinase alleles driven by Nanos3. Alliance mouse Nanos3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nanos3 Mutation: 28 strains or lines available

References

• Original: J:136687 Suzuki H, et al., Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Dev Biol. 2008 Jun 1;318(1):133-42
• All: 11 reference(s)