F2rl1^tm2Cgh
Targeted Allele Detail

Summary

• Symbol: F2rl1^tm2Cgh
• Name: F2R like trypsin receptor 1; targeted mutation 2, Shaun R Coughlin
• MGI ID: MGI:4358416
• Synonyms: PAR2-lacZ
• Gene: F2rl1 Location: Chr13:95648240-95661735 bp, - strand Genetic Position: Chr13, 49.53 cM
• Alliance: F2rl1^tm2Cgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76348
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-floxed PGK-neomycin cassette was inserted in such a way that the endogenous ATG start site was replaced. The lacZ reporter construct was then expressed by the F2rl1 promoter. (J:76348, J:157446)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F2rl1 Mutation: 60 strains or lines available

References

• Original: J:76348 Camerer E, et al., Genetic Evidence That Protease-activated Receptors Mediate Factor Xa Signaling in Endothelial Cells. J Biol Chem. 2002 May 3;277(18):16081-7
• All: 2 reference(s)