Tg(Prnp-TARDBP*A315T)95Balo
Transgene Detail

Summary

• Symbol: Tg(Prnp-TARDBP*A315T)95Balo
• Name: transgene insertion 95, Robert Baloh
• MGI ID: MGI:4358722
• Synonyms: Prp-TDP43-A315T, Prp-TDP43^A315T, Prp-TDP43A315T
• Transgene: Tg(Prnp-TARDBP*A315T)95Balo Location: unknown Genetic Position: Chr9, Syntenic
• Alliance: Tg(Prnp-TARDBP*A315T)95Balo page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-TARDBP*A315T)95Balo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TARDBP (23435)

  Tardbp

  (MGI:2387629)

• Mutation details: The construct contains the full-length human TAR DNA binding protein (TARDBP or TDP-43) cDNA sequence that was modified to harbor an N-terminal Flag tag immediately after the start methionine and the A315T amino acid substitution associated with familial ALS inserted between exon 2 and exon 3 of mouse prion protein (PrP or Prnp) gene. A single Prp-TDP43A315T founder line was established (founder line 95) mapping to two close but distinct sites on Chr 9: Chr9:38,417,354 and Chr9:38,405,898 (coordinates from MGSC ver 37, mm9). (J:153197)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:153197 Wegorzewska I, et al., TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18809-14
• All: 52 reference(s)