Lcktm1.1Litt
Targeted Allele Detail
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Symbol: |
Lcktm1.1Litt |
Name: |
lymphocyte protein tyrosine kinase; targeted mutation 1.1, Dan R Littman |
MGI ID: |
MGI:4358985 |
Gene: |
Lck Location: Chr4:129442142-129467415 bp, - strand Genetic Position: Chr4, 63.26 cM, cytoband distal
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Alliance: |
Lcktm1.1Litt page
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Germline Transmission: |
Earliest citation of germline transmission:
J:152472
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Cre recombination removes exons 1 through 3. Due to a cryptic splice site cre recombination of this allele produces a truncated transcript lacking the amino-terminal myristylation sequence, the CD4/CD8-interaction domain, and the epitope recognized by the 1F6 monoclonal antibody. This transcipt is generated from thymic transcipts that derive from the proximal promoter but not from the peripheral T cell transcripts deriving from the distal promoter.
(J:152472)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lck Mutation: |
95 strains or lines available
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Original: |
J:152472 Kim JK, et al., Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking. PLoS One. 2009;4(8):e6580 |
All: |
1 reference(s) |
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