Nmur2^tm1.1Eege
Targeted Allele Detail

Summary

• Symbol: Nmur2^tm1.1Eege
• Name: neuromedin U receptor 2; targeted mutation 1.1, Emil Egecioglu
• MGI ID: MGI:4359163
• Gene: Nmur2 Location: Chr11:55915816-55931813 bp, - strand Genetic Position: Chr11, 33.39 cM
• Alliance: Nmur2^tm1.1Eege page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152493
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a floxed neo cassette. Germ line, cre mediated recombination removed the neo cassette. The absence of exon 1-containing transcript expression was confirmed by RT-PCR on brain, cerebellum and spinal cord extracts. (J:152493)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nmur2 Mutation: 28 strains or lines available

References

• Original: J:152493 Egecioglu E, et al., Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice. Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E708-16
• All: 1 reference(s)