Pros1^tm1.1Ansc
Targeted Allele Detail

Summary

• Symbol: Pros1^tm1.1Ansc
• Name: protein S (alpha); targeted mutation 1.1, Anne Angelillo-Scherrer
• MGI ID: MGI:4359168
• Synonyms: Pros^-
• Gene: Pros1 Location: Chr16:62674670-62749709 bp, + strand Genetic Position: Chr16, 36.43 cM
• Alliance: Pros1^tm1.1Ansc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152423
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination removes exons 3 through 7. The decreased protein expression was confirmed by western blot analysis on plasma from heterozygous mice. (J:152423)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pros1 Mutation: 44 strains or lines available

References

• Original: J:152423 Saller F, et al., Generation and phenotypic analysis of protein S-deficient mice. Blood. 2009 Sep 10;114(11):2307-14
• All: 5 reference(s)