Gpbar1^tm1.2Auw
Targeted Allele Detail

Summary

• Symbol: Gpbar1^tm1.2Auw
• Name: G protein-coupled bile acid receptor 1; targeted mutation 1.2, Johan Auwerx
• MGI ID: MGI:4359279
• Synonyms: TGR5^-, TGR5^L-
• Gene: Gpbar1 Location: Chr1:74317709-74318783 bp, + strand Genetic Position: Chr1, 38.53 cM
• Alliance: Gpbar1^tm1.2Auw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152388
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Germ line, cre mediated recombination removed exon 1. (J:152388)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpbar1 Mutation: 30 strains or lines available

References

• Original: J:152388 Thomas C, et al., TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 2009 Sep;10(3):167-77
• All: 22 reference(s)