Kdm1b^tm1.1Tche
Targeted Allele Detail

Summary

• Symbol: Kdm1b^tm1.1Tche
• Name: lysine (K)-specific demethylase 1B; targeted mutation 1.1, Taiping Chen
• MGI ID: MGI:4359289
• Synonyms: Aof1^1loxP
• Gene: Kdm1b Location: Chr13:47196849-47238085 bp, + strand Genetic Position: Chr13, 24.5 cM
• Alliance: Kdm1b^tm1.1Tche page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152382
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed beta-Geo cassette was inserted in intron 16 and an additional loxP site was inserted in intron 13. Exons 14-16 are thus flanked by loxP sites. Mice were crossed with transgenic mice carrying an unspecified Zp3-cre transgene to excise exons 14-16 and the beta Geo cassette. (J:152382)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm1b Mutation: 63 strains or lines available

References

• Original: J:152382 Ciccone DN, et al., KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature. 2009 Sep 17;461(7262):415-8
• All: 2 reference(s)