Tg(Gpbar1)1Auw
Transgene Detail

Summary

• Symbol: Tg(Gpbar1)1Auw
• Name: transgene insertion 1, Johan Auwerx
• MGI ID: MGI:4359293
• Synonyms: TGR5-Tg
• Transgene: Tg(Gpbar1)1Auw Location: unknown
• Alliance: Tg(Gpbar1)1Auw page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Gpbar1)1Auw expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gpbar1 (MGI:2653863)

• Mutation details: The BAC RP23-278N11 was used to make a transgene expressing Gpbar1. It was modified to contain the rabbit beta-globin intron, an inactive cre/ERT2 fusion, and frt-flanked neo cassette downstream of the Vil1 promoter for genotyping purposes. The neo cassette was removed by germ line, flp mediated recombination. One line was created with 6 copies of the transgene and Gpbar1 expression restricted to most tissues normally expression Gpbar1. (J:152388)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:152388 Thomas C, et al., TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 2009 Sep;10(3):167-77
• All: 4 reference(s)