Nceh1^tm1Ishi
Targeted Allele Detail

Summary

• Symbol: Nceh1^tm1Ishi
• Name: neutral cholesterol ester hydrolase 1; targeted mutation 1, Shun Ishibashi
• MGI ID: MGI:4359388
• Gene: Nceh1 Location: Chr3:27237153-27299112 bp, + strand Genetic Position: Chr3, 10.82 cM
• Alliance: Nceh1^tm1Ishi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152385
• Parent Cell Line: JH1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain and kidney extract. (J:152385)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nceh1 Mutation: 35 strains or lines available

References

• Original: J:152385 Sekiya M, et al., Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis. Cell Metab. 2009 Sep;10(3):219-28
• All: 4 reference(s)