Angptl2^tm1Yo
Targeted Allele Detail

Summary

• Symbol: Angptl2^tm1Yo
• Name: angiopoietin-like 2; targeted mutation 1, Yuichi Oike
• MGI ID: MGI:4359444
• Gene: Angptl2 Location: Chr2:33106081-33137729 bp, + strand Genetic Position: Chr2, 22.36 cM
• Alliance: Angptl2^tm1Yo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152387
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 including the ATG transcription start site was replaced with a lacZ reporter construct and a floxed neomycin cassette. Gene inactivation was confirmed by Northern blot analysis on homozygous skin extracts. (J:152387)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angptl2 Mutation: 35 strains or lines available

References

• Original: J:152387 Tabata M, et al., Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab. 2009 Sep;10(3):178-88
• All: 12 reference(s)