Ryr2^tm1.1Wex
Targeted Allele Detail

Summary

• Symbol: Ryr2^tm1.1Wex
• Name: ryanodine receptor 2, cardiac; targeted mutation 1.1, Xander Wehrens
• MGI ID: MGI:4359589
• Synonyms: Ryr2^S2814A
• Gene: Ryr2 Location: Chr13:11567988-12121831 bp, - strand Genetic Position: Chr13, 4.38 cM, cytoband A1-A2
• Alliance: Ryr2^tm1.1Wex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152544
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Nucleotide substitutions Mutation details: Exon 56 was replaced with one containing nucleotide substitutions that result in the amino acid substitution of alanine for serine at position 2814 (S2814A). The modified exon was followed by a floxed neo cassette that was removed by subsequent germ line, cre mediated recombination. (J:152544)

Generation of the Ryr2^tm1.1Wex allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ryr2 Mutation: 325 strains or lines available

References

• Original: J:152544 Chelu MG, et al., Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009 Jul;119(7):1940-51
• All: 18 reference(s)