Themis^Spotr
Chemically induced Allele Detail

Summary

• Symbol: Themis^Spotr
• Name: thymocyte selection associated; single positive thymoycte reduction
• MGI ID: MGI:4359649
• Synonyms: E430004N04Rik^Spotr, Themis^T512P
• Gene: Themis Location: Chr10:28544356-28759814 bp, + strand Genetic Position: Chr10, 16.06 cM
• Alliance: Themis^Spotr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis caused a missense mutation in exon 4 of the gene where adenine was changed to a cystosine at position 1779 (A1779C). This resulted in a threonine-to-proline substitution at position 512 (T512P). Protein expression was significantly depressed in homozygote thymocytes compared to wild-type while mRNA levels were unaffected. (J:152601)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Themis Mutation: 57 strains or lines available

References

• Original: J:152601 Kakugawa K, et al., A novel gene essential for the development of single positive thymocytes. Mol Cell Biol. 2009 Sep;29(18):5128-35
• All: 1 reference(s)