Ebag9^tm1Rehm
Targeted Allele Detail

Summary

• Symbol: Ebag9^tm1Rehm
• Name: estrogen receptor-binding fragment-associated gene 9; targeted mutation 1, Armin Rehm
• MGI ID: MGI:4359722
• Gene: Ebag9 Location: Chr15:44482571-44504911 bp, + strand Genetic Position: Chr15, 16.91 cM, cytoband D1
• Alliance: Ebag9^tm1Rehm page

Altered size of secretory lysosomes in Ebag9^tm1Rehm/Ebag9^tm1Rehm cytotoxic T lymphocytes

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152534
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 2-4, which contains the translational start site, were replaced with a neomycin resistance cassette. Gene inactivation was confirmed by a lack of signal in immunoblot analysis of homozygote lymph node lysates. (J:152534)

Generation of the Ebag9^tm1Rehm allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ebag9 Mutation: 22 strains or lines available

References

• Original: J:152534 Ruder C, et al., The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells. J Clin Invest. 2009 Aug;119(8):2184-203
• All: 2 reference(s)