Dp(7Herc2-Mkrn3)1Taku
Targeted Allele Detail

Summary

• Symbol: Dp(7Herc2-Mkrn3)1Taku
• Name: duplication, Chr 7, Toru Takumi 1
• MGI ID: MGI:4359729
• Synonyms: 15q Dup, Dp
• Gene: Dp(7Herc2-Mkrn3)1Taku Location: Chr7:55699944-62069887 bp Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151648
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted
• Mutation: Duplication
• Dp(7Herc2-Mkrn3)1Taku involves 291 genes/genome features (Gm22466, Gm23873, Gm23490 ...) View all
• Mutation details: Sequential rounds of targeting inserted the selection cassettes and loxP sites proximal to Herc2 and distal to Mkrn3. A double-targeted clone in which the targeting had occurred on the homologous chromosomes (trans) was transiently transfected with a Cre recombinase in ES cells to induce recombination between the loxP sites on opposite chromosomes, which generated clones with a balanced duplication and deletion of 6.3 Mb region between Herc2 and Mkrn3. Only duplicated allele can be recovered after meiosis and mating. (J:151648)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dp(7Herc2-Mkrn3)1Taku Mutation: 1 strain or line available

References

• Original: J:151648 Nakatani J, et al., Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell. 2009 Jun 26;137(7):1235-46
• All: 18 reference(s)