Grk5^tm2Rjl
Targeted Allele Detail

Summary

• Symbol: Grk5^tm2Rjl
• Name: G protein-coupled receptor kinase 5; targeted mutation 2, Robert J Lefkowitz
• MGI ID: MGI:4359730
• Synonyms: GRK5 flox
• Gene: Grk5 Location: Chr19:60878187-61084406 bp, + strand Genetic Position: Chr19, 56.52 cM
• Alliance: Grk5^tm2Rjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152746
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 7 and 8 were flanked by loxP sites and a neomycin resistance cassette followed by a loxP site was placed in intron 8. Transient transfection with cre recombinase excised the neomycin resistance cassette, leaving exons 7 and 8 floxed. (J:59179, J:152746)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grk5 Mutation: 44 strains or lines available

References

• Original: J:152746 Lefkowitz RJ, Generation of a Grk5 floxed allele. MGI Direct Data Submission. 2009
• All: 7 reference(s)