Ccr6^tm1.1Jmf
Targeted Allele Detail

Summary

• Symbol: Ccr6^tm1.1Jmf
• Name: C-C motif chemokine receptor 6; targeted mutation 1.1 Joshua M Farber
• MGI ID: MGI:4359772
• Gene: Ccr6 Location: Chr17:8454875-8475973 bp, + strand Genetic Position: Chr17, 4.9 cM, cytoband A1
• Alliance: Ccr6^tm1.1Jmf page

Ccr6^tm1.1Jmf/Ccr6^tm1.1Jmf mice are resisant to IL23-induced acanthosis and dermal inflammation

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152716
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: A targeting cassette consisting of an EGFP downstream of an internal ribosome entry site and a floxed neomycin resistance gene replaced positions 3094-3611 in the open reading frame of the gene. The neomycin cassette was subsequently removed by crossing chimera mice with transgenic mice expressing cre recombinase in the germline. Gene inactivation was confirmed by flow cytometry analysis of activated, homozygote B cells. Low levels of GFP expression were detected in activated B cells but not in other activated lymphocytes suggesting reporter gene expression does not recapitulate expression of the endogenous locus. (J:152716)

Generation of the Ccr6^tm1.1Jmf allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccr6 Mutation: 37 strains or lines available

References

• Original: J:152716 Hedrick MN, et al., CCR6 is required for IL-23-induced psoriasis-like inflammation in mice. J Clin Invest. 2009 Aug;119(8):2317-29
• All: 8 reference(s)