Bcar3^tm1Lern
Targeted Allele Detail

Summary

• Symbol: Bcar3^tm1Lern
• Name: breast cancer anti-estrogen resistance 3; targeted mutation 1, Adam Lerner
• MGI ID: MGI:4359826
• Synonyms: AND-34^-
• Gene: Bcar3 Location: Chr3:122213406-122323840 bp, + strand Genetic Position: Chr3, 53.41 cM, cytoband G3
• Alliance: Bcar3^tm1Lern page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152504
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 and most of exon 5 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis of splenic lymphocyte extracts. (J:152504)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcar3 Mutation: 68 strains or lines available

References

• Original: J:152504 Near RI, et al., Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens. Mol Vis. 2009;15:685-99
• All: 1 reference(s)