Tg(Prnp-RTN3)2Yanr
Transgene Detail

Summary

• Symbol: Tg(Prnp-RTN3)2Yanr
• Name: transgene insertion 2, Riqiang Yan
• MGI ID: MGI:4359884
• Synonyms: hRTN3, RTN3-Tg2, Tg-RTN3, Tg-RTN3 line2
• Transgene: Tg(Prnp-RTN3)2Yanr Location: unknown
• Alliance: Tg(Prnp-RTN3)2Yanr page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-RTN3)2Yanr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RTN3 (10313)

  Rtn3	(MGI:1339970)

• Mutation details: The hRTN3 transgene was designed with a C-terminally myc-tagged human reticulon 3 (RTN3) cDNA inserted between exon 2 and exon 3 of mouse prion protein (PrP or Prnp) gene at two unique XhoI sites in the Mo-Prp.Xho plasmid vector. This transgene was microinjected into the male pronuclei of fertilized FVB/N oocytes. Mice from founder line 2 (RTN3-Tg2) were bred with C57BL/6J mice to establish the colony. Line 2 expressed 1-2-fold higher levels of reticulon 3 compared to wild-type. (J:122560)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:122560 Hu X, et al., Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities. EMBO J. 2007 Jun 6;26(11):2755-67
• All: 4 reference(s)