Ghr^tm1.2Masp
Targeted Allele Detail

Summary

• Symbol: Ghr^tm1.2Masp
• Name: growth hormone receptor; targeted mutation 1.2, Mark A Sperling
• MGI ID: MGI:4359895
• Gene: Ghr Location: Chr15:3347237-3612834 bp, - strand Genetic Position: Chr15, 1.84 cM
• Alliance: Ghr^tm1.2Masp page

Small body size of Ghr^tm1.2Masp/Ghr^tm1.2Masp mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152627
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Germ line, cre mediated recombination removed exon 4. (J:152627)

Generation of the Ghr^tm1.1Masp and Ghr^tm1.2Masp alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ghr Mutation: 50 strains or lines available

References

• Original: J:152627 Fan Y, et al., Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem. 2009 Jul 24;284(30):19937-44
• All: 2 reference(s)