Gpx5^tm1115.2Arte
Targeted Allele Detail

Summary

• Symbol: Gpx5^tm1115.2Arte
• Name: glutathione peroxidase 5; targeted mutation 1115.2, TaconicArtemis
• MGI ID: MGI:4359923
• Synonyms: Gpx5^{tm1115_.2Arte}
• Gene: Gpx5 Location: Chr13:21470599-21476897 bp, - strand Genetic Position: Chr13, 7.73 cM, cytoband A2-A4
• Alliance: Gpx5^tm1115.2Arte page

Cauda epididymidis-retrieved spermatozoa from Gpx5^tm1115.2Arte/Gpx5^tm1115.2Arte mice suffer oxidative damage

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152563
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Germ line, cre mediated recombination removed exon 2. The absence of protein expression was confirmed by western blot analysis on caput epididymidis extracts. (J:152563)

Generation of the Gpx5^tm1115.1Arte and Gpx5^tm1115.2Arte alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpx5 Mutation: 17 strains or lines available

References

• Original: J:152563 Chabory E, et al., Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice. J Clin Invest. 2009 Jul;119(7):2074-85
• All: 1 reference(s)