Kif7^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Kif7^tm1Lex
• Name: kinesin family member 7; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:4360052
• Gene: Kif7 Location: Chr7:79347846-79365468 bp, - strand Genetic Position: Chr7, 45.09 cM, cytoband D2
• Alliance: Kif7^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152551
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a lacZ gene and neo cassette. This insertion deletes the ATG initiation codon and 109 amino acids. (J:152551)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Kif7 Mutation: 40 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:152551 Endoh-Yamagami S, et al., The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr Biol. 2009 Aug 11;19(15):1320-6
• All: 3 reference(s)