Dact1tm1.1Bnrc
Targeted Allele Detail
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Symbol: |
Dact1tm1.1Bnrc |
Name: |
dishevelled-binding antagonist of beta-catenin 1; targeted mutation 1.1, Benjamin N R Cheyette |
MGI ID: |
MGI:4360072 |
Synonyms: |
Dact1neodelta |
Gene: |
Dact1 Location: Chr12:71356658-71366881 bp, + strand Genetic Position: Chr12, 29.39 cM
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Alliance: |
Dact1tm1.1Bnrc page
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Spectrum of posterior defects in Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc and Dact1tm1.1Bnrc/Dact1tm1.1Bnrc mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:152701
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A targeting vector was designed to insert a frt-flanked neomycin resistance (neo) cassette, followed by a loxP site, upstream of exon 2, and a second loxP site downstream of exon 6. Cre-mediated recombination then removed exon 2. Western blot analysis confirmed the absence of protein expression in uterine tissue from homozygous mice.
(J:152701)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Dact1 Mutation: |
21 strains or lines available
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Original: |
J:152701 Suriben R, et al., Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet. 2009 Sep;41(9):977-85 |
All: |
4 reference(s) |
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