Tg(Nodal-cre)16Hmd
Transgene Detail

Summary

• Symbol: Tg(Nodal-cre)16Hmd
• Name: transgene insertion 16, Hiroshi Hamada
• MGI ID: MGI:4360082
• Synonyms: NDE-Cre, Tg(NodalNDE-cre)16Hmd
• Transgene: Tg(Nodal-cre)16Hmd Location: unknown
• Alliance: Tg(Nodal-cre)16Hmd page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Nodal-cre)16Hmd expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Nodal

• Mutation details: This transgene comprises two tandem copies of a 0.7-kb DNA fragment containing the node-specific enhancer (NDE) of the Nodal gene, 1.2 kb of 5' flanking DNA from the Nodal locus containing the promoter, and the Cre recombinase coding sequence. Beta-galactosidase expression in progeny of mice with this transgene and animals bearing a lacZ Cre reporter transgene is first detected by X-Gal staining in the region of the posterior node of 2-somite-stage embryos; this activity becomes stronger as the embryos develop. (J:82703, J:104881)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nodal (species not specified) Summary of all recombinase alleles driven by Nodal. Comparative matrix view of recombinase activities

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Zic3^tm1.1Smwa/Y Tg(Nodal-cre)16Hmd/0	involves: C57BL/6

Phenotypes:

Affected Systems	cn1
show or hide all annotated terms Sex:
normal phenotype	√
no abnormal phenotype detected	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:82703 Saijoh Y, et al., Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol. 2003 Apr 1;256(1):160-72
• All: 5 reference(s)