Notch2^{Gt(betageo)1Byg}
Gene trapped Allele Detail

Summary

• Symbol: Notch2^{Gt(betageo)1Byg}
• Name: notch 2; gene trap 1, BayGenomics
• MGI ID: MGI:4360085
• Synonyms: Notch2^lacZ
• Gene: Notch2 Location: Chr3:97920854-98057683 bp, + strand Genetic Position: Chr3, 42.42 cM
• Alliance: Notch2^{Gt(betageo)1Byg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146621
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A beto-geo construct inserted into the locus creating a null allele. Reporter gene expression was detected in subsets of B cells. (J:146621)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch2 Mutation: 99 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:146621 Tan JB, et al., Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches. Immunity. 2009 Feb;30(2):254-63
• All: 2 reference(s)